1.2.10必交作业1、【简答题】一患者感冒后进食大量桃罐头，引起低钾血症，请联系细胞生物学知识进行解释。
2、【资料题】美洲新大陆的哥伦布船队和率领船队环绕地球一周的航海家麦哲伦船队的多名船员因大出血而死亡，请阐明这些船员的发病原因及机制。
1.3.10必交作业1、【单选题】一个21岁的妇女因皮肤脆弱、弹性过强，容易发生皮下血肿、瘢痕形成差、关节过度伸展前来就诊。经检查发现，在col5a1基因的编码原胶原a肽链的信号肽有突变。请问下列哪一项将由该突变导致的？
a、合成的原胶原a肽链不能从内质网中运出
b、原胶原a肽链在合成过程中不能转运至内质网
c、原胶原a肽链从高尔基体运回到内质网
d、原胶原a肽链被运送到溶酶体
e、前胶原分子不能组装成胶原原纤维
2、【单选题】一个6个月大的婴儿因发育落后（体重和身长增长缓慢，远低于同龄人）而被带到儿科诊所。通过功能测试、电镜检查和血液检查，诊断他患的是一种遗传性疾病称为i（inclusion，包含）-细胞病，他的细胞中先天性缺乏n-乙酰葡萄糖胺磷酸转移酶 （n-acetylglucosamine-1-phosphotransferase，简称磷酸转移酶），该磷酸转移酶能够磷酸化修饰甘露糖形成6-磷酸甘露糖。下列哪种情况可以解释该病人的细胞生物过程改变？
a、溶酶体酶被错误的运回到高尔基体中
b、过氧化物酶体被错误地运到其它细胞器中
c、异常的kdel序列
d、囊泡上缺乏snare蛋白
e、溶酶体酶被分泌出细胞外
1.5.1必交作业1、【单选题】the symptoms of a certain inherited disorder in humans include respiratory problems and, in males, sterility. which of the following is a reasonable hypothesis for the molecular basis of this disorder?
a、defective actin molecules in cellular microfilaments
b、defective dynein molecules in cilia and flagella
c、abnormal hydrolytic enzymes in the lysosomes
d、a defective secretory protein
e、a defective enzyme in the mitochondria
1.6.3必交作业1、【单选题】a 20-month-old boy is diagnosed with hutchinson-gilford progerial syndrome (hgps), a severe form of early-onset premature aging. fetal and early postnatal development are normal, but there is now severe failure to thrive, some lipoatrophy, bony abnormalities, a small, beaked nose and receding mandible, hair loss, and speckled hypopigmentation with some areas of tight hard skin. his neurological and cognitive tests are normal. genetic analysis shows a single spontaneous mutation in codon 608 of the lmna gene, which encodes both lamin a and lamin c. which one of the following would you most likely expect to be a direct effect in cells obtained from this patient?
a、increased heterochromatin
b、interference with microtubule treadmilling
c、increased synthesis of rrna in the nucleolus
d、loss of ability to adhere to the basement membrane through integrins
e、aberrations in nuclear architecture
1.7.4必交作业1、【单选题】dolastatin 11 is a promising chemotherapeutic depsipeptide that arrests mitotic cells in the process shown in the accompanying electron micrograph. which one of the following would be a possible mechanism for dolastatin?
a、lengthening of kinetochore microtubules
b、contraction of a ring composed of cytoskeletal elements
c、shortening of polar microtubules
d、dysregulation of the m-cdk complex (mpf)
e、disruption and rearrangement of cellular actin